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Limitations of this study include its descriptive, observational design, with no statistical comparisons of outcomes within or between treatment cohorts

TBRp over 24 hours remained stable around 4% throughout pregnancy in both groups

For instance, in patients with systemic lupus erythematosus (SLE), autoantibodies directed against doublestranded DNA (dsDNA) and nucleosomes can trigger the activation of DCs via TLR2 when complexed HMGB1

PLoS Med

To more precisely examine the extent to which mitochondrial GSH depletion impacts erythropoiesis, we additionally generated a mouse model in which mitochondrial GSH import is disrupted specifically in the erythroid lineage (conditional SLC25a39-KO mice, ErGFP-cre